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Are There Renal Adenocarcinoma-free Populations of Leopard Frogs?¹

Department of Biology, Newcomb College of Tulane University, New Orleans, Louisiana 70118

Some populations of the northern leopard frog, Rana pipiens, are afflicted with a prevalent malignant renal tumor. Our purpose in this study was to ascertain whether leopard frogs collected from previously unstudied areas of North Dakota and Louisiana have, or are susceptible to, renal adenocarcinomas.

No renal tumors were detected by autopsies of 932 North Dakota leopard frogs and 466 Louisiana leopard frogs. Adult frogs from North Dakota and larvae from Louisiana were subjected to tumor-promoting conditions. Tumors developed in North Dakota frogs held at 20–22° for about 8 months. Louisiana frogs, given injections of a cell-free extract of a renal adenocarcinoma, developed typical renal adenocarcinomas at metamorphosis.

¹ This study was supported by grants from the American Cancer Society, Inc. (E-369-B) and the Damon Runyon Memorial Fund for Cancer Research, Inc. (DRG 990).

² Present address: Department of Zoology, University of Minnesota, Minneapolis, Minn. 55455.

Received 3/18/70. Accepted 7/28/70.