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Induction of Cancer by 20-Methylcholanthrene in Different Regions of the Rat Stomach

Laboratory of Carcinogenesis of the Institute of Nutrition of the Academy of Medical Sciences, Moscow, U.S.S.R.

We have developed a new method of application of carcinogen to the mucosa of any region of the stomach in rats. By means of an oval fastener and globular polyethylene ampul, a pocket from the stomach wall is formed in which blood circulation and innervation are kept uninterrupted. Ampuls with different numbers of apertures in walls and lipid vehicles with different melting points were investigated.

Cardiac, fundal, and pyloric regions of the stomach and the forestomach were subjected to the effect of 20-methyl-cholanthrene for 16 months. The forestomach is the most susceptible to the effect of carcinogen (17 tumors in 27 rats). The greatest susceptibility to carcinogenesis of the 3 regions of the glandular stomach is in the cardiac region (9 tumors in 30 rats), and the least is in the fundal region (2 tumors in 31 rats).

Received 4/ 9/70. Accepted 7/10/70.