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A Growth-modifying Factor from Cell Lines of Human Malignant Origin

Pasadena Foundation for Medical Research, Pasadena, California 91101

A growth-modifying factor was detected in the culture media derived from flask cultures of three established lines of human malignant origin. The growth-modifying factor migrated electrophoretically like prealbumin, was antigenic, and showed hyaluronidase activity. This protein stimulated fibroblastic growth at low concentrations but stopped mitosis and was cytotoxic to fibroblasts at high concentrations. Lines of identity in an immunodiffusion system suggested that a common antigen was being produced by carcinoma cells of divergent sources but was not produced by fibroblasts.

Received 6/ 8/70. Accepted 8/ 6/70.