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Effect of Enzyme Induction on the Metabolism and Tissue Distribution of Benzo()pyrene¹

The The Wellcome Research Laboratories, Burroughs Wellcome & Co. (U. S. A.) Inc., Tuckahoe, New York 10707

Pretreatment of rats with benzo()pyrene, 3-methylcholanthrene, or 7,12-dimethylbenz()anthracene p.o. once daily for two days prior to the i.v. administration of tritiated benzo()-pyrene (BP-³H) on the third day stimulates the disappearance of BP-³H from blood and decreases the concentration of BP-³H in various tissues. Pretreatment of rats with pyrene, anthracene, or phenobarbital does not stimulate the in vivo disappearance of BP-³H. The concentration of BP-³H in the fat of rats is lower after seven daily p.o. doses of BP-³H than after a single dose of BP-³H, which suggests that this hydrocarbon stimulates its own metabolism during chronic administration.

¹ This study was supported in part by Research Contract PH 43-65-1066 from the Pharmacology-Toxicology Programs, National Institute of General Medical Sciences, NIH.

² Present address: Pharmakologisches Institut der Freien Universität, (Abt. Embryonal-Pharmakologie), 1 Berlin-Dahlem (33), Thielallee 69/73, West Germany.

³ Present address: Department of Biochemistry, Hoffmann-La Roche, Inc., Nutley, N. J. 07110.

⁴ Present address: Technicon Corporation, 511 Benedict Avenue, Tarrytown, N. Y. 10591.

Received 5/ 1/70. Accepted 8/19/70.

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