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A Ganglioneuroma in the Adrenal Medulla of a Rat Bearing a Preoptic-Anterior Hypothalamic Lesion¹

Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts 01545, and The Mallory Institute of Pathology, Boston City Hospital, Boston, Massachusetts 02118

A rare adrenal medullary tumor, a ganglioneuroma, was found in a male Sprague-Dawley rat which had received a large unilateral lesion of the preoptic-anterior hypothalamus 9 months prior to being sacrificed at 1 year of age. The tumor, which occupied most of the adrenal medulla, consisted of mature ganglion cells imbedded in neural tissue. No medullary tumors were found in 26 additional animals with lesions (4 unilateral and 22 bilateral) and 40 control animals. However, ganglion cells were found in the medulla of approximately one-third of the rats with or without lesions, and neural tissue was present in approximately two-thirds of the rats with or without lesions. Evidence linking central nervous system control to medullary differentiation is discussed.

¹ Supported by National Institute of Mental Health Training Grant 5 TO1 MH-10625. A preliminary report on these experiments was given at the annual meetings of the Eastern Psychological Association, April 1970. A manuscript completely describing the results is in preparation.

² To whom correspondences should be addressed, at Massachusetts College of Pharmacy, 179 Longwood Ave., Boston, Mass. 02115.

Received 7/13/70. Accepted 8/28/70.