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Structure of the Glycine-rich, Arginine-rich Histone of the Novikoff Hepatoma¹

Department of Pharmacology, Baylor College of Medicine, Houston, Texas 77025

The glycine-rich, arginine-rich histone of Novikoff hepatoma was hydrolyzed with trypsin, chymotrypsin, and thermolysin. The peptides obtained were analyzed and compared to similar peptides from the calf thymus glycine-rich, arginine-rich histone (14).

Thirteen tryptic peptides were analyzed, and three were sequenced. Six chymotryptic and seven thermolysin peptides were analyzed.

On the basis of similarity of the peptides isolated from Novikoff hepatoma and calf thymus glycine-rich, arginine-rich histones, it seems evident that the two histone structures are essentially identical.

¹ This work was supported in part by Welch Foundation Grant Q-272, American Cancer Society Grant P-369, and Cancer Research Center Grant CA-10893.

² Predoctoral trainee of the USPHS Grant CA-5154.

Received 6/25/70. Accepted 9/ 2/70.