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The Oncogenicity of Two 1,1-Diaryl-2-propynyl N-Cycloalkylcarbamates¹

Division of Toxicology [P. N. H., W. R. G.], Eli Lilly and Company, Greenfield, Indiana 46140, and Division of Chemical Research [R. D. D.], Eli Lilly and Company, Indianapolis, Indiana 46206

1,1-Bis(4-fluorophenyl)-2-propynyl N-cyclooctylcarbamate and 1,1-bis(4-fluorophenyl)-2-propynyl N-cycloheptylcarbamate were fed to rats for 3 months, and then all surviving animals were killed for necropsy. With the cyclooctyl compound, 18 of an effective number of 25 rats developed malignant lymphoma; 2 developed malignant lymphoma and colonic adenocarcinoma; and 2 developed ileal adenocarcinoma. The first tumor was found after 55 days. With the cycloheptyl compound, 19 of an effective number of 37 rats developed malignant lymphoma; 1 developed malignant lymphoma and mammary adenocarcinoma; and 2 developed mammary adenocarcinoma. The first tumor was found after 54 days.

¹ Presented in part at the 60th Annual Meeting of the American Association for Cancer Research, San Francisco, Calif., March 23, 1969.

Received 5/ 4/70. Accepted 9/ 3/70.