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Effect of Starvation of Intact and Adrenalectomized Mice Bearing Lymphosarcoma P1798 on Tumor Regression and Ribonuclease Activity¹

Medical Service, National Cancer Institute, Baltimore Cancer Research Center, Baltimore, Maryland 21211

Starvation of BALB/c mice bearing Lymphosarcoma P1798 resulted in regression of both the corticoid-resistant and corticoid-sensitive tumor strain. Increased acid-specific ribonuclease activity of whole tumor homogenates accompanied regression of the corticoid-sensitive strain from intact animals but not the corticoid-resistant strain. Adrenalectomy prevented the increase in tumor RNase activity induced by starvation in the corticoid-sensitive strain. Enhancement of specific RNase activity in the corticoid-sensitive strain of P1798 after starvation may be due to increased endogenous glucocorticoid secretion secondary to stress, but increased tumor RNase activity is not necessary for tumor regression to occur. Both the corticoid-sensitive and -resistant strains of P1798 regressed after starvation, and adrenalectomy of the host did not prevent regression of corticoid-sensitive P1798. Therefore, starvation-induced regression of the corticoid-sensitive tumor may not be mediated by endogenous glucocorticoid secretion, and the mechanism of starvation-induced regression remains unclear.

¹ Requests for reprints should be addressed to the author at 3100 Wyman Park Drive, Baltimore, Md. 21211.

Received 4/28/69. Accepted 6/12/69.