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The Biocleavage of Alkyl Glyceryl Ethers in Morris Hepatomas and Other Transplantable Neoplasms¹

Medical Division, Oak Ridge Associated Universities,⁴ Oak Ridge, Tennessee 37830

This study compares the ether-cleaving ability of normal rat liver homogenate with various transplantable tumor homogenates. The results show that the cleavage system is the most active in normal rat liver and Morris Hepatoma 7794A, much less active in Hepatoma 7777, and very low or absent in the other tumors tested. These data demonstrate that neoplasms that contain high levels of O-alkyl-diacylglycerols do not have an active alkyl ether cleavage system.

¹ This work has been supported in part by the American Cancer Society Grant P-470, and NIH Grant GM12562-06.

² U. S. Atomic Energy Commission Postdoctoral Fellow.

³ School of Pharmacy, University of North Carolina, Chapel Hill, N. C. 27515.

⁴ Under contract with the U. S. Atomic Energy Commission.

Received 4/24/69. Accepted 6/19/69.

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