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Further Studies on Liver Glyoxalase Activity in Mice Bearing Lymphosarcoma¹

Departments of Biological Sciences and Chemistry, North Texas State University, Denton, Texas 76203

An appreciable decrease in the normal glyoxalase activity was observed in the livers of DBA/1J mice bearing tumors (lymphosarcoma) 12 days after implantation. It was found that the extent of this decrease varies somewhat with the age of the mice used in the study. The activities of glutamicoxaloacetic transaminase and isocitric acid dehydrogenase in the livers of the tumor-bearing mice follow activity patterns similar to those in hepatoma. In mice bearing lymphosarcoma the activities of liver glyoxalase and glutamicoxaloacetic transaminase vary appreciably as the tumor develops, while the activity of isocitric acid dehydrogenase remains essentially invariant. Implications of these observations are discussed.

¹ This work was supported in part by Faculty Research Funds, North Texas State University, Grants B-133 and B-268 from the Robert A. Welch Foundation of Texas, and NIH Grant (CA-07527-04).

Received 1/16/69. Accepted 6/23/69.