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Cyclic Nucleotides on Cell Growth in Vitro¹

Eppley Institute for Cancer Research, University of Nebraska College of Medicine, Omaha, Nebraska 68105

The growth of four tumorigenic cell lines was inhibited from 70 to 89% by adenosine 3', 5'-cyclic monophosphate (0.3 mM) whereas a nonmalignant cell line (WI-38) was affected only slightly (13%). Adenosine 2',3'-cyclic monophosphate (0.3 mM) was less active, inhibiting the tumorigenic cell lines from 23 to 56%.

The other cyclic purine nucleotides investigated (guanosine 3',5'-cyclic monophosphate and quanosine 2',3'-cyclic monophosphate) did not show selectivity; they inhibited the tumorigenic strains and the WI-38 cell line.

The 3',5'-cyclic pyrimidine nucleotides, with the exception of thymidine 3',5'-cyclic monophosphate, did not significantly inhibit any of the cell lines. Thymidine 3',5'-cyclic monophosphate produced inhibition of only strain L.

¹ This research was supported by a Research Grant P-384C from the American Cancer Society.

² Predoctoral trainee, USPHS Traineeship 2-TO1-HD-18.

Received 5/ 7/69. Accepted 7/16/69.

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