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The Cellular Proliferation Kinetics of Animal Tumors¹

Medical Physics Department, Royal Postgraduate Medical School, Ducane Road, London W. 12, England

The growth rates of four transplantable rodent tumors have been analyzed in terms of their cell cycle time, growth fraction, and rate of loss of cellular material from the tumor volume. A correlation was found between the cell cycle time and the volume doubling time of the three sarcomas. This correlation did not apply to the carcinoma. All four tumors contained nonproliferating cells; the growth fractions varied from 37% to 60%. The volume doubling time, predicted from the labeling index and the duration of DNA synthesis, was closely similar to the measured volume doubling time in the two rapidly growing sarcomas; in the slow-growing sarcoma and the carcinoma there was a considerable discrepancy between the two. For the carcinoma this is attributed to loss of cellular material from the tumor volume, but it is thought that differentiated cell products may be influencing this measurement in the sarcoma.

An analysis of kinetic data in the literature, obtained from other experimental solid tumors, shows some general trends in agreement with the results obtained from these four tumors.

¹ Financial support was received from the Medical Research Council and the British Empire Cancer Campaign.

Received 3/21/69. Accepted 6/12/69.