This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Theilen, G. H. Articles by Harrold, J. B. Search for Related Content PubMed PubMed Citation Articles by Theilen, G. H. Articles by Harrold, J. B.

Experimental Induction of Lymphosarcoma in the Cat with "C"-type Virus¹

Departments of Clinical Sciences and Pathology, School of Veterinary Medicine, University of California, Davis, California 95616

A detailed clinicopathological description of experimentally induced leukemia in cats is presented. A predominance of immature lymphoid cells was found in neoplastic lesions of both donor and experimental kittens. Tumor tissue from donor and experimental cats had a "starry sky" pattern that resulted from distribution of large histiocytic macrophages within the neoplastic mass.

"C"-type leukemogenic virus was found in plasma and a variety of cells of both donor and experimental cats. The mature virion had an outer diameter of 115 mµ and an electron-dense nucleoid measuring 90 mµ. The immature particle consisted of an outer unit membrane envelope that measured 115 mµ, an electron-dense inner ring that measured 65 mµ in diameter, and an electron-lucent center that measured 45 mµ in diameter.

The possible spectrum of disease caused by "C"-type feline leukemogenic virus, reasons for short latent period of 6 to 8 weeks in recipient animals, and its possible public health importances are presented.

¹ Supported in part by United States Department of Agriculture Grant 529-15-1, General Research Support Grant 68-124, cancer research funds of the University of California, and USPHS Grant PHS43-65-609 in the Special Viral Cancer Program, National Cancer Institute.

Received 10/25/68. Accepted 6/ 6/69.

This article has been cited by other articles:

				M Essex, A Sliski, S. Cotter, R. Jakowski, and W. Hardy Jr Immunosurveillance of naturally occurring feline leukemia Science, November 21, 1975; 190(4216): 790 - 792. [Abstract] [PDF]