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Experimental Induction of Lymphosarcoma in the Cat with "C"-type Virus¹

Departments of Clinical Sciences and Pathology, School of Veterinary Medicine, University of California, Davis, California 95616

A detailed clinicopathological description of experimentally induced leukemia in cats is presented. A predominance of immature lymphoid cells was found in neoplastic lesions of both donor and experimental kittens. Tumor tissue from donor and experimental cats had a "starry sky" pattern that resulted from distribution of large histiocytic macrophages within the neoplastic mass.

"C"-type leukemogenic virus was found in plasma and a variety of cells of both donor and experimental cats. The mature virion had an outer diameter of 115 mµ and an electron-dense nucleoid measuring 90 mµ. The immature particle consisted of an outer unit membrane envelope that measured 115 mµ, an electron-dense inner ring that measured 65 mµ in diameter, and an electron-lucent center that measured 45 mµ in diameter.

The possible spectrum of disease caused by "C"-type feline leukemogenic virus, reasons for short latent period of 6 to 8 weeks in recipient animals, and its possible public health importances are presented.

¹ Supported in part by United States Department of Agriculture Grant 529-15-1, General Research Support Grant 68-124, cancer research funds of the University of California, and USPHS Grant PHS43-65-609 in the Special Viral Cancer Program, National Cancer Institute.

Received 10/25/68. Accepted 6/ 6/69.

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