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Comparison of Tumorigenesis and of Long-Term Development of Ovarian Autografts on the Greater Omentum of Castrated Infantile and Mature Rats

Endocrinological Department of the Rogoff-Wellcome Medical Research Institutes, Beilinson Hospital, Petah Tikva, Israel

Castration and concurrent implantation of a fragment of the ovary have been performed in two groups of rats, 3 weeks and 14 weeks old. The animals (125 young and 129 mature) were killed in groups after 3, 6, 7, 8, 9, and 12 months. The development of the implants was examined and statistical comparisons were made between the two age groups.

The implants grew always faster in the young than in the older animals, pointing to differences in intrinsic growth properties of ovaries in rats of different ages.

Fatty degeneration of the implants was less pronounced in the younger animals and lasted for a shorter time.

Foci of granulosa cell tumors appear for the first time in both groups at 6 months after operation. Between 6 and 8 months their number was 2 to 3 times higher in the younger age group than in the older one.

At every time interval in both groups of animals the fastest growing implants were the most prone to tumorigenesis.

Although the mean weights of the implants bearing foci of granulosa cell tumors were always higher in the younger animals than those of the older ones at comparable time intervals, statistically significant differences have been obtained only after 12 months, when the implants were nearly completely transformed into granulosa cell tumors.

Received 1/ 3/69. Accepted 6/12/69.