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Effect of Purine-Protein Conjugates on the Ehrlich Ascites Tumor in Mice¹

Israel Institute for Biological Research, Ness-Ziona, Israel

Purine-protein conjugates induce regression of transplanted Ehrlich ascites tumor in mice. The antitumor activity coincides with the ability of the conjugates to elicit antinuclear antibodies in the host and depends more on the structure of the purine residue than on the origin of the carrier protein. Tumor rejection may be due to the stimulation by these antigens of a specific but otherwise repressed response in the host.

¹ Supported by Grant CA-06996 from the National Cancer Institute, NIH, Bethesda, Md.

Received 3/12/69. Accepted 7/ 7/69.