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The Mitogenic Activity of a C57BL/10 Mouse Transplantable Lymphoma¹

Division of Biology, California Institute of Technology, Pasadena, California 91109 [B. G. S., M. W.], and Department of Cytogenetics and Cytology, City of Hope Medical Center, Duarte, California 91010 [R. L. T.]

A C57BL/10 transplantable lymphoma was found to stimulate waves of partially synchronized host-cell multiplication in the spleens of mice into which lymphoma cells had been injected. This mitogenic action of the lymphoma was not limited to living cells but was found also in X-ray-inactivated cells and in the supernatant from centrifuged suspensions of these cells. The mitogenic factor was not erythropoietin. It did not seem to reflect an antigenic stimulation of the host-spleen response.

The lymphoma transgressed H-2 histocompatibility barriers in some transfers and it killed hosts of the line of origin more rapidly than it killed hybrid mice with one parent from the line of tumor origin.

¹ This research was supported by Grant AEC AT-04040642 (B. G. S.) and USPHS Grant CA 08791-02. (R. L. T.).

² Present address: Department of Zoology, University of Texas, Austin, Texas 78712.

Received 7/22/68. Accepted 6/16/69.