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Tumor Production in the Glandular Stomach and Alimentary Tract of the Rat by N-Methyl-N'-nitro-N-nitrosoguanidine¹

National Cancer Center Research Institute, Tsukiji, Chuo-ku, Tokyo, Japan

Oral administration of N-methyl-N'-nitro-N-nitrosoguanidine to rats at levels of 33 to 167 µg/ml in the drinking water resulted in a high percentage of adenomas and adenocarcinomas of the glandular stomach. Additionally, rats that were examined after 1 year of experiment showed a variety of other tumors in the duodenum, the jejunum, the liver, and the mesentery. N-Methyl-N'-nitro-N-nitrosoguanidine is a tool for facile production of adenocarcinoma in the glandular stomach of rats.

¹ Paper 2 in a series dealing with the production of gastric cancer. For Paper 1 see Reference 25. This work was supported by Ministry of Education Grants 9322 and 9316 and grants from the Mitsui Life Foundation of Welfare and the Society for Promotion of Cancer Research.

² Present address: Laboratory of Cell Research, Cancer Institute, Kyushu University, Fukuoka, Japan.

Received 3/25/69. Accepted 6/ 2/69.

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