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Immunology of the Mouse Mammary Tumor Virus: Comparison of the Antigenicity of Mammary Tumor Virus Obtained from Several Strains of Mice¹

Department of Bacteriology and Immunology, and the Cancer Research Genetics Laboratory, University of California, Berkeley, California 94720

Reaction of mammary tumor virus (MTV) antigen in immunodiffusion, with the use of rabbit antisera, has been used for the detection of antigenic similarities and differences among MTV "strains" obtained from different strains of mice. Cross-reactivity among samples of a soluble MTV antigen from virus originally obtained from C3H, C3Hf, A, RIII, DBA, WILD, or GR mice has been demonstrated. A similar cross-reacting antigenicity exists among the preparations of MTV B-particles from the various virus "strains." In addition to the antigenic cross-reactivity, some evidence of antigenic dissimilarity was observed in the various MTV B-particle preparations; the MTV derived from C3Hf mice and that derived from wild house mice appear to lack at least one antigenic component possessed by MTV from other sources, such as MTV of C3H or DBA origin. Speculations on the significance of these antigenic similarities and differences are included.

¹ Supported by Grant PRA-37 from the American Cancer Society, Inc., by USPHS Grant CA-05388 from the National Cancer Institute, and by cancer research funds of the University of California.

Received 6/ 2/69. Accepted 7/30/69.