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Evidence for the Presence of Anti-Burkitt Tumor Globulins in Pooled Human Immune Globulins

Division of Biologics Standards, NIH, Bethesda, Maryland 20014

Each of 20 commercially prepared lots of human immune globulins tested produced specific immunofluorescence reactions with EB3 cells, a continuous cell strain derived from Burkitt's lymphoma. The immunofluorescence titers ranged from 1:80 to 1:640. Each of these 20 lots also suppressed growth of EB3 cell cultures. Complement was not required for these reactions. There was good correlation between the immunofluorescence and growth suppression titers. Suppression of cellular growth was related to the extent of EB virus infection in 6 human lymphoma and leukemia cell culture lines tested. The globulins responsible for the growth suppression and immunofluorescence reactions were partially 2-mercaptoethanol sensitive and were absorbed by EB3 cells but not by human amnion cells.

¹ Present address: Department of Microbiology, University of Maryland, College Park, Md. 20742.

Received 6/30/69. Accepted 8/27/69.