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The Effect of the Antitumor Agent 1,1-Diphenyl-2-propynyl Cyclohexylcarbamate on the Immune Response of Mice to Sheep Red Blood Cells¹

Department of Developmental Therapeutics, The University of Texas M. D. Anderson Hospital and Tumor Institute at Houston, Houston, Texas 77025

The effect of 1,1-diphenyl-2-propynyl cyclohexylcarbamate on hemagglutinin and hemolysin formation by mice in response to sheep red blood cells has been investigated. A single LD₁₀ dose of drug was administered at various times before or after immunization and the hemagglutinin response was evaluated. With this dose the drug, depending on time of administration in relation to primary immune exposure, will block the development of both 19 S and 7 S hemagglutinins, augment 19 S hemagglutinin formation, or selectively suppress 7 S hemagglutinin production. The LD₁₀ dose also interferes with the secondary hemagglutinin response. Here, it is most effective when given simultaneously with antigen. The 19 S hemolysin response is suppressed by a dose of drug less than one-half of the LD₁₀ dose. Suppression of hemolysins is most marked when the drug is given 24 hr before antigen.

¹ Supported in part by Grant FRO-5511 from the National Cancer Institute, NIH, Bethesda, Md. 20014.

² Present address: Faculty of Medicine, University of Ottawa, Ottawa General Hospital, Ottawa, 2, Ontario, Canada.

Received 5/26/69. Accepted 8/25/69.