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The Effect of Limited Administration of N-Methyl-N'-nitro-N-nitrosoguanidine on the Induction of Stomach Cancer in Rats¹

Biochemistry Division, National Cancer Center Research Institute, Tsukiji, Chuo-ku [S. F., K. K., and T. S.], and Experimental Pathology Division, Cancer Institute, Japanese Foundation for Cancer Research, Nishi-sugamo, Toshima-ku [S. T.], Tokyo, Japan

N-Methyl-N'-nitro-N-nitrosoguanidine (NG) in the drinking water of male Wistar rats for 7 months followed by tap water for 3 to 6 months produced more adenocarcinomas of the glandular stomach than did continuous administration of NG for 1 year or more. However, continuous administration, or a higher concentration of NG for 7 months, led to more tumors of the forestomach, small intestine, or mesentery.

¹ Paper III in a series dealing with production of gastric cancer. For Paper II see Ref. 5. This work was supported partly by Grants 9316 and 9322 from the Ministry of Education, Japan, the Society for Promotion of Cancer Research, and the Mitsui Life Foundation of Welfare.

Received 4/29/69. Accepted 8/19/69.