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Virus-induced Hemolytic Anemia in Mice¹

Departments of Pediatrics and Pathology, University of Chicago, Pritzker School of Medicine, Chicago, Illinois 60637

Mouse erythroblastosis virus induces splenomegaly, anemia, and thrombocytopenia in infected animals. ⁵¹Cr-Labeled red cell survival studies and serial blood counts indicate that the anemia is due to red cell destruction and the splenomegaly is due to a compensatory hyperplasia of erythrocytic precursors. Splenectomy prevents the secondary reticulocytosis, but it does not prevent the red cell destruction. Electron microscopy of peripheral blood from mice infected with mouse erythroblastosis virus demonstrates budding virus particles at platelet and reticulocyte cell surfaces.

¹ This work was supported by funds from the Leukemia Research Foundation.

Received 8/ 4/69. Accepted 10/ 1/69.