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Binding of 7,12-Dimethylbenz(a)anthracene and Benzo(a)pyrene to Nucleic Acids and Proteins of Organs in Rats¹

Istituto di Patologia Generale, Universita di Bologna, 40126 Bologna, Italy

The activity of DNA, rRNA, nuclear and cytoplasmic proteins of liver, spleen, kidneys, lung, and skin, after i.p. injection into rats of tritiated 7,12-dimethylbenz(a)anthracene (DMBA) and benzo(a)pyrene (BP) has been examined. The amount bound to proteins is higher than that bound to nucleic acids and is different in the various organs, without correlation between the level of activity of proteins and nucleic acids.

DMBA is bound to a higher extent than BP. The ratio DMBA/BP is much higher for the nucleic acids than for the proteins; this indicates a "preference" of DMBA for nucleic acids as compared with BP.

¹ This work was supported by a grant from Consiglio Nazionale delle Ricerche, Rome, Italy.

Received 7/ 7/69. Accepted 10/ 2/69.