This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Patterson, M. K. Articles by Maxwell, M. D. Search for Related Content PubMed PubMed Citation Articles by Patterson, M. K., Jr. Articles by Maxwell, M. D.

Effects of L-Asparagine Deprivation on the Cell Cycle of the Jensen Sarcoma

Biomedical Division, The Samuel Roberts Noble Foundation, Inc., Ardmore, Oklahoma 73401

The phases of the cell cycle G₁, S, and G₂, but not M, of the Jensen sarcoma were inhibited following L-asparagine deprivation. Repletion with the amino acid showed the effect to be reversible within one cycle time. Repletion during S phase was followed by an increased rate of DNA synthesis, suggesting the role of L-asparagine in initiator protein synthesis.

Received 9/ 8/69. Accepted 10/10/69.

This article has been cited by other articles:

				I. P. Barbosa-Tessmann, C. Chen, C. Zhong, S. M. Schuster, H. S. Nick, and M. S. Kilberg Activation of the Unfolded Protein Response Pathway Induces Human Asparagine Synthetase Gene Expression J. Biol. Chem., October 29, 1999; 274(44): 31139 - 31144. [Abstract] [Full Text] [PDF]