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Morphology of Virus-like Particles Persisting in Murine Ependymoblastoma in Vitro¹

Department of Medicine, Roosevelt Hospital, New York 10019 [R. P. A.], the Henry and Lucy Moses Research Laboratories of the Laboratory Division, Montefiore Hospital, New York 10067, and the Department of Neurological Surgery of the Albert Einstein College of Medicine, New York, New York 10061 [R. C. R.]

Virus-like particles were recently described in an ependymoblastoma of C57BL/J mice. For characterization of these particles, the tumor was explanted into cell culture. This study reports the growth of these cells in culture and the persistence of virus-like particles in the cells for up to 5 months in culture. The particles correspond to intracytoplasmic A particles and extracellular enveloped A and B particles of the murine RNA tumor group. The particles meet all the morphological criteria of the mammary tumor agent. Two unusual findings of this study are the occurrence of B particles in nonmammary tissue and their long-term persistence in tissue culture.

¹ This investigation was supported by the Whitehall Foundation and NIH Grant NB0551. This work was presented in part to the American Federation of Experimental Biology, Atlantic City, N. J., April 17, 1969 (2).

Received 7/ 2/69. Accepted 10/16/69.