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Dermal Collagen Changes during 2-Aminoanthracene Carcinogenesis in the Rat¹

Division of Dermatology, University of Oregon Medical School, Portland, Oregon 97201, and Department of Biochemistry, University of Oregon Medical School, Portland, Oregon 97201 [J. P. B.]

A dermal collagen alteration precedes the onset of epidermal neoplasia during experimental carcinogenesis in the skin of a variety of animals. The alteration appears histologically as a fragmentation, rarefaction, and fraying of the fibers. Since these changes could represent a defect in collagen metabolism, the synthesis, extracellular aggregation, and breakdown of this protein were specifically studied with a tritiated proline tracer in young Sprague-Dawley rats treated topically with the carcinogen 2-aminoanthracene. A statistically significant depression of collagen synthesis localized to the carcinogen-painted site was found. This response was independent of growth rate and inflammation. Collagen aggregation and breakdown were uninfluenced by the carcinogenic treatment. The pertinence of these findings to epitheliomesenchymal interactions and to epidermal carcinogenesis is discussed.

¹ This work was supported by USPHS Grants CA-06111 and CA-10016 and Training Grant 5-TI-AM-5300.

Received 7/18/69. Accepted 10/23/69.

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