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Comparative Carcinogenicity in the Rat of 2-Hydrazinothiazoles with Nitrofuryl, Nitrophenyl, or Aminophenyl Substituents in the 4-Position¹

The Division of Clinical Oncology, University of Wisconsin Medical School, Madison, Wisconsin 53706 [S. M. C., E. E., G. T. B.], and Scientific Divisions, Abbott Laboratories, North Chicago, Illinois 60064 [J. M. P.]

2-Hydrazino-4-(5-nitro-2-furyl)thiazole, 2-(2, 2-dimethylhydrazino)-4-(5-nitro-2-furyl)thiazole, 2-hydrazino-4-(4-nitrophenyl)thiazole, and 2-hydrazino-4-(4-aminophenyl)thiazole were fed to female Sprague-Dawley rats, and all were found to be potent carcinogens. Each induced chiefly carcinomas of the mammary gland (32/35, 30/31, 27/34, 34/35, respectively), as well as a lower incidence of tumors of other organs. The carcinogenic relationship of these four compounds to formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl]hydrazide is discussed.

¹ Supported in part by Grants CA-10017 and CA-10341, and Contract PH 43-66-888 from the National Cancer Institute, and by a grant from the Wisconsin Division of the American Cancer Society.

² Medical Scientist Trainee of National Institute of General Medical Sciences (GM-01932).

³ Career Development Awardee of the National Cancer Institute (1-K4-CA-8245-01A1).

Received 5/29/69. Accepted 8/28/69.