This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Cohen, S. M. Articles by Bryan, G. T. Search for Related Content PubMed PubMed Citation Articles by Cohen, S. M. Articles by Bryan, G. T.

Carcinogenicity of Formic Acid 2-[4-(5-Nitro-2-furyl)-2-thiazolyl]-hydrazide in Swiss Mice¹

Division of Clinical Oncology, University of Wisconsin Medical School, Madison, Wisconsin 53706

Formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl] hydrazide was fed to 50 female 5-week-old Swiss mice at a dose of 0.1% by weight of diet for a total of 29 weeks, with a cumulative dose of 1.2 g/mouse/29 weeks. Because of acute toxicity of the chemical and cannibalization by other mice, only 22 of 50 mice survived to the end of feeding and were evaluated. Fifty-six control mice received control diet, and 44 survived and were evaluated.

Formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl] hydrazide appeared to be a strong carcinogenic (21/22) and leukemogenic (19/22) chemical in this animal species. The solid tumors induced included squamous cell and adenocarcinoma of the stomach (21/22), alveolar lung carcinomas (9/22), mammary adenocarcinomas (7/22), and single tumors of the uterus and skin. In the control mice, the following tumor incidences were found: generalized leukemias, 15/44; and lung, 1/44.

¹ Supported in part by Grant CA-10341 from the National Cancer Institute, USPHS, and by a grant from the Wisconsin Division of the American Cancer Society.

² Medical Scientist Trainee of the National Institute of General Medical Sciences, USPHS (GM-01932).

³ Career Development Awardee of the National Cancer Institute, USPHS. (1-K4-CA-8245-01A1).

Received 7/17/69. Accepted 9/10/69.