This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Breedis, C. Articles by Kreider, J. W. Search for Related Content PubMed PubMed Citation Articles by Breedis, C. Articles by Kreider, J. W.

The Role of the Dermis in the Induction of Neoplasia by Shope Papilloma Virus¹

Department of Pathology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 [C. B.] and Department of Pathology, College of Medicine, Pennsylvania State University, Hershey, Pennsylvania 17033 [J. W. K.]

Interactions of mesenchyme with epithelial cells are known to be responsible for the survival, proliferation, and differentiation of embryonic and adult epithelia of a variety of phenotypes. The importance of the dermis in the induction of neoplasia in rabbit epidermis infected with Shope papilloma virus was studied. Skin fragments were dissociated into epidermal and dermal components with trypsin, infected with Shope papilloma virus, and grafted to nondermal sites. The results were consistent with the view that little or no dermis is required for the development of typical Shope papillomas from Shope papillomas virus-infected epidermal cells.

¹ Supported by USPHS Grants CA-10320-01 and 1-R01-CA11097-01A1.

² Recipient of USPHS Research Career Development Award 7-K4-CA38,809-01A1.

Received 7/29/69. Accepted 9/19/69.

This article has been cited by other articles:

				A. A. McBride, A. Dlugosz, and C. C. Baker Production of infectious bovine papillomavirus from cloned viral DNA by using an organotypic raft/xenograft technique PNAS, May 9, 2000; 97(10): 5534 - 5539. [Abstract] [Full Text] [PDF]