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Stimulation of DNA Synthesis of Rat Salivary Gland Cells in Monolayer Cultures by Isoproterenol¹

Department of Pathology, College of Medicine, Pennsylvania State University, Hershey, Pennsylvania 17033.

Isoproterenol is a potent stimulator of DNA synthesis of salivary glands. The exact mechanism of its action is not clear. It is possible that isoproterenol may act directly upon salivary gland cells or that its effects may be mediated as a secondary phenomenon from prime effects on another tissue or organ system. In this report, evidence is presented that isoproterenol can directly stimulate DNA synthesis of cell cultures obtained from rat salivary glands.

¹ Supported by USPHS Grant 1-R01-CA11097-01A1.

² Recipient of USPHS Research Career Development Award 7-K4-CA-38809-01A1.

Received 8/ 5/69. Accepted 9/22/69.