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Lack of Correlation between Morphological and Biochemical Parameters in Mammary Adenocarcinomas of Rats Induced with 7, 12-Dimethylbenz(a)anthracene¹

Squibb Institute for Medical Research, New Brunswick, New Jersey 08903 [R. H., H. G.], and Fels Research Institute, Temple University School of Medicine, Philadelphia, Pennsylvania 19140 [M. G., D. R. M., M. B. S.]

Mammary tumors induced by 7,12-dimethylbenz(a)-anthracene were divided into slow- and fast-growing neoplasms on the basis of growth rate. Biochemical and histological evaluation was performed on each group and the data were compared. Of the 21 different parameters examined, significant differences were found in 3: isocitrate dehydrogenase and hexokinase activities and triglyceride content. None of the parameters demonstrated any correlation with growth rate, although there were many coordinated biochemical changes.

¹ Supported by Contract PH43-65-1050, Endocrine Evaluation Branch, General Laboratories and Clinics, National Cancer Institute, NIH, and in part by Grant CA-07771, National Cancer Institute, NIH, USPHS.

² Present address: Biochemistry Department, University of Rochester School of Medicine and Dentistry, Rochester, N. Y. 14620.

³ Present address: Coordinator, Regional Medical Program, School of Medicine, University of California, San Diego, 7816A Ivanhoe Avenue, La Jolla, Calif. 92037.

Received 7/29/69. Accepted 12/ 8/69.