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Induction of Cerebral Gliomas in Rats with Dietary Lead Subacetate and 2-Acetylaminofluorene¹

Division of Pathology, Presbyterian-St. Luke's Hospital, Chicago, Illinois 60612

In a study of neoplasms induced by 2-acetylaminofluorene (2-AAF) and lead subacetate, 25 gliomas and 3 extracerebral intracranial tumors were found in 988 Wistar and cesarean-delivered (Sprague-Dawley) rats, of which 663 were in experimental and 325 in control groups. The tumors usually developed after 52 weeks of age. Most tumors were classified as poorly differentiated malignant gliomas. The highest incidence (8.6%) of gliomas was in animals ingesting lead subacetate and the difference compared with the incidence (0.3%) among controls was statistically significant (p < 0.05). In animals given 2-AAF with or without oliver oil, carbon tetrachloride, or ethionine, the incidence (2.5%) of gliomas was lower and their development was usually delayed until after 60 weeks of age but the incidence (5.5%) among rats that survived 60 weeks or more was statistically significant (p < 0.05) when compared with that of 325 control rats in which only 1 glioma was found. Unsuccessful attempts were made to increase the incidence of gliomas by combining lead subacetate with 2-AAF management and by local freezing of the brain in the early stage of prolonged 2-AAF dietary treatment.

¹ This work was supported by Grants 2G-129, NB 04872, NB 03677, CA 05378, and CA 11036 from NIH, USPHS, and the Grant H. Laing Research Funds.

² USPHS Postdoctoral Research Trainee in Pathology 2G-129.

Received 8/ 8/69. Accepted 11/12/69.