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Urinary Bladder Carcinogenicity of N-[4-(5-Nitro-2-furyl)-2-thiazolyl]formamide in Female Swiss Mice¹

Division of Clinical Oncology, University of Wisconsin Medical School, Madison, Wisconsin 53706

N-[4-(5-Nitro-2-furyl)-2-thiazolyl]formamide was fed to 50 female 5-week-old Swiss mice at a dose of 0.094% by weight of diet for 46 weeks, followed by 7 weeks of the control diet. Fifty-six mice received only the control diet. Thirty-three test mice survived 40 weeks or longer and had the following tumor incidences: urinary bladder, 31/33; generalized leukemia, 23/33; lung, 6/33; and 1 uterine tumor. In the controls, the following tumor incidences were found: generalized leukemia, 15/44; and lung, 1/44.

¹ Supported in part by Grant CA-10017 from the National Cancer Institute, USPHS, and by a grant from the Wisconsin Division of the American Cancer Society.

² Medical Scientist Trainee of the National Institute of General Medical Sciences, USPHS, GM-01932.

³ Career Development Awardee of the National Cancer Institute, USPHS, 1-K4-CA-8245-01A1.

Received 7/31/69. Accepted 11/20/69.

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