This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Dimitrov, N. V. Articles by Brodsky, I. Search for Related Content PubMed PubMed Citation Articles by Dimitrov, N. V. Articles by Brodsky, I.

Asparagine Metabolism in Some Lymphoproliferative Disorders¹

Department of Medicine, Section of Hematology, Hahnemann Medical College, Philadelphia, Pennsylvania 19102, and Philadelphia General Hospital, Philadelphia, Pennsylvania 19104

Lymphocytes obtained from normal individuals and patients with acute lymphocytic leukemia, chronic lymphocytic leukemia, and lymphosarcoma with leukemic blood picture were incubated with uniformly labeled asparagine-¹⁴C. The intermediary metabolism was followed by determination of radioactivity in respiratory CO₂, protein, lipids, organic acids, and free amino acids. The greatest quantitative and qualitative changes in asparagine metabolism were found in lymphosarcoma with leukemic blood picture. Chronic lymphocytic leukemia resembled the normal pattern with acute lymphocytic leukemia occupying an intermediate position. With progression of chronic lymphocytic leukemia, changes in asparagine metabolism occurred.

¹ This investigation was supported by USPHS Grants CA 11060 and CA 08725, General Research Support, USPHS Grant 5508, Philadelphia General Hospital, and assistance from Merck, Sharp and Dohme.

Received 8/ 6/69. Accepted 12/ 5/69.