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Transplantable Adenocarcinomas of the Rat Kidney Possessing Different Growth Rates

Laboratory of Biochemistry, National Cancer Institute, NIH, USPHS, HEW, Bethesda, Maryland 20014 [H. P. M., B. P. W.], and Fels Research Institute, Philadelphia, Pennsylvania 19140 [D. R. M.]

Three transplantable kidney adenocarcinomas were induced in Buffalo strain rats ingesting 4'-fluoro-4-biphenylacetamide. Although all are comparatively slowly growing, these three transplantable neoplasms have different growth rates. Histologically, they are well-differentiated adenocarcinomas, composed of generally uniform cells resembling kidney tubular cells, and they appear to be only slightly deviated from normal kidney tissue. Focal microscopic lesions similar to the larger neoplasms were noted in other portions of the kidneys in which the tumors developed. No pulmonary metastases have been observed.

¹ Present address: Department of Biochemistry, Howard University College of Medicine, Washington, D. C. 20001.

Received 10/29/69. Accepted 12/18/69.