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Inhibiting Effect of Reserpine and Female Sensitivity in Hepatic Tumor Induction with 2,7-Diacetamidofluorene in SMA/Ms Strain Mice

The Second Department of Pathology, Nagoya University School of Medicine, Nagoya, Japan

Repeated injection of reserpine and simultaneous administration of 2,7-diacetamidofluorene in SMA/Ms strain mice prevented the development of liver tumors but failed to induce gastric cancer. Female mice developed more hepatic tumors than males both in the carcinogen groups and in the reserpine-treated group. Castration increased the formation of hepatic cancer in male mice but not in females. In castrated female mice, estradiol benzoate had little effect and testosterone propionate reduced liver tumor incidence somewhat.

Received 8/25/69. Accepted 12/29/69.