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Fine Structure of Nuclear Inclusions in Murine Pulmonary Tumor Cells¹

Department of Experimental Pathology and Cancer Research, University of Leeds, School of Medicine, Leeds, England

Lung tissue explants from BALB/c mice were exposed to 20-methylcholanthrene in organ culture and then implanted into isologous hosts. The tumors which arose in the implants were adenomata and adenocarcinomata. Some of the latter were serially transplanted. Electron microscopic observations were made on 3 types of nuclear inclusions found in these tumors and their probable mode of formation was described. Intranuclear membranous tubules appeared to be involved in the biogenesis of the true nuclear inclusions.

¹ This investigation was supported by the Yorkshire Council of the British Empire Cancer Campaign.

² Present address: Department of Pathology, The Medical School, University of Bristol, Bristol, England.

Received 9/15/69. Accepted 1/16/70.