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Production of Tumors in Glandular Stomach of Hamsters by N-Methyl-N'-nitro-N-nitrosoguanidine¹

Biochemistry [S. F., K. K., T. S.] and Pathology [S. O.] Divisions, National Cancer Center Research Institute, Tsukiji, Chuo-ku, Tokyo, Japan

N-Methyl-N'-nitro-N-nitrosoguanidine was administered continuously to 26 male Golden hamsters at a concentration of 83 µg/ml in drinking water. Twenty fibrosarcomas in the glandular stomach and 3 adenocarcinomas and 2 fibrosarcomas in the duodenum were observed in animals that died after 6 to 10 months. In almost all the cases of fibrosarcomas in the glandular stomach, atypical glandular epithelial proliferation infiltrating into submucosa or muscle layer was also present.

¹ This is Paper IV in a series dealing with the production of gastric cancer. For Papers I, II, and III see Refs. 3, 5, and 6. This work was supported partly by Grants 9322 and 9316 from the Ministry of Education, a grant from the Mitsui Life Foundation of Welfare, and a grant from the Society for Promotion of Cancer Research.

Received 10/27/69. Accepted 1/16/70.

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