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Rapid Induction of Subcutaneous Fibrosarcoma by 7,12-Dimethylbenz(a)anthracene in an Inbred Line of Syrian Hamsters¹

Bio-Research Institute, Cambridge, Massachusetts 02141

Single s.c. injections of 500 µg 7,12-dimethylbenz(a)-anthracene in tricaprylin were given to 25 males and 25 females of 10 inbred strains of Syrian hamsters. In 9 strains, the average time of latency before palpable tumors appeared was 13 to 16 weeks. In 1 strain, BIO 15.16, the average latency was 10 weeks. These differences are statistically significant. In this line, the first palpable tumors appeared in both sexes 5 weeks following carcinogen injection. All animals of this line developed tumors within 15 weeks after carcinogen injection [there was a single exception in a male (included in the average latency) wherein a tumor developed 34 weeks after injection]. Histologically, the tumors were fibrosarcomas invading the subcutaneous musculature and morphologically indistinguishable from similarly induced tumors in other strains. There were few metastases; all tumors tested grew upon subcutaneous transplantation into hamsters of the same as well as of unrelated strains.

¹ This investigation was supported by USPHS Research Grant CA 10101 from the National Cancer Institute, NIH.

Received 9/29/69. Accepted 1/19/70.