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On the Oncogenic Properties of Chicken Embryo Lethal Orphan Virus, an Avian Adenovirus¹

Department of Surgery, The University of Texas Southwestern Medical School, Dallas, Texas 75235 [R. F. J., B. B. A.], and Department of Veterinary Pathology, The Ohio State University School of Veterinary Medicine, Columbus, Ohio 43210 [D. S. Y.]

The oncogenicity of chicken embryo lethal orphan virus for newborn hamsters has been confirmed. Tumor incidence was found to be a function of the titer of the virus inoculum. Fifty-four % (7/13) of the hamsters given 10^9.3 50% lethal dose developed tumors, while only 8% (8/99) of the hamsters given 10^9.0 50% lethal dose developed tumors. With a single exception, lower virus doses were nononcogenic; one tumor developed among 26 hamsters given virus inactivated from 10^8.7 to 10^4.0 50% lethal dose by nitrous acid. Although all the tumors were of mesenchymal origin a variety of sarcomatous types were noted. The latent period varied from 14 to 52 weeks and all but one tumor appeared at the site of injection. Female hamsters appeared more susceptible than males. Indirect immunofluorescence and complement-fixation tests failed to demonstrate antibody in the sera of tumor-bearing hamsters to autologous tumor extracts or to chicken embryo lethal orphan virus-infected chick and hamster embryo cells.

¹ Supported in part by Special Research Fellowship 7-F3-CA-12, 618-O1A1 and Research Grant CA-07745, both from the National Cancer Institute, NIH. Most of these studies were performed in the Department of Viral Oncology at Roswell Park Memorial Institute, while Dr. Yohn was Associate Research Scientist and Dr. Jones was an NIH Special Research Fellow.

Received 4/28/69. Accepted 1/26/70.

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