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Acute Changes in Nucleic Acid and Protein Synthesis in the Mouse Bladder Epithelium Induced by Three Bladder Carcinogens¹

Department of Experimental Pathology and Cancer Research, School of Medicine, Leeds, LS2 9NL, Great Britain

The effect of a single oral dose of 4-ethylsulfonylnaphthalene-1-sulfonamide, 2-acetylaminofluorene, and 3-aminodibenzofuran on DNA, RNA, and protein synthesis in the urinary bladder and liver of the mouse has been investigated. Each chemical stimulated RNA and DNA synthesis in the bladder, but the magnitude and timing of the response was different in each case. Administration of 4-ethylsulfonylnaphthalene-1-sulfonamide in the diet produced an increase in DNA synthesis in the mouse bladder which lasted for 4 weeks, whereas with 2-acetylaminofluorene, increased DNA synthesis occurred only during the first week. The effect of 4-ethylsulfonyl-naphthalene-1-sulfonamide on nucleic acid synthesis was specific for the bladder, whereas 2-acetylaminofluorene stimulated both RNA and DNA synthesis in the liver and 3-aminodibenzofuran induced a small increase in DNA synthesis in male, but not in female, mouse liver.

¹ This work was supported by the Yorkshire Council of the British Empire Cancer Campaign for Research.

² Present address: Department of Pathology, University of Queensland, Medical School, Brisbane, Queensland 4006, Australia.

Received 6/ 9/69. Accepted 1/26/70.

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