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Morphological Studies on Transmissible Feline Fibrosarcoma¹

Departments of Pathology [S.P.S., W.P.C.R.] and Clinical Sciences [G.H.T.], School of Veterinary Medicine, University of California, Davis, California 95616

Inoculations s.c. of cell-free Millipore filtrates of the S-T feline sarcoma virus resulted in the rapid induction of fibrosarcomas in kittens. Metastatic tumors, seen in a large percentage of the inoculated kittens, were of two distinct types. The first was a solid tumor, similar to the tumors located in the subcutaneous tissue. The second type, seen primarily in the liver and brain, was formed by numerous, cystic, blood-filled cavities surrounded by a thin shell of neoplastic cells. Ultrastructural studies confirmed light microscopic findings of three cell types in all solid tumors: fibroblasts, macrophage-like cells, and mast cells. C-type viral particles seen in tumor tissue of the original source cat with spontaneous fibrosarcomas and from all inoculated experimental kittens were uniform in morphology and apparent mode of production and were similar to those of feline leukemia. The findings help to substantiate the viral etiology of this feline fibrosarcoma.

¹ Supported in part by United States Drug Administration Grant 529-15-1, General Research Support Grant 68-124, Cancer Research Funds of the University of California, and USPHS Contract 43-65-609 in the Special Viral Cancer Program.

² Postdoctoral Fellow, USPHS Grant 2T1-GM 537.

Received 9/ 4/69. Accepted 1/29/70.