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Transfer RNA Patterns in Livers of Rats Fed Diets Containing 3'-Methyl-4-dimethylaminoazobenzene¹

Department of Biochemistry, The University of Texas M. D. Anderson Hospital and Tumor Institute at Houston, Houston, Texas 77025

Albino rats were fed diets containing the hepatocarcinogen 3'-methyl-4-dimethylaminoazobenzene for approximately 8 weeks. At this time, tRNA was prepared from the livers of these animals and control animals. The tRNA's were charged with labeled amino acids and cochromatographed on reversed phase columns. Some major differences were observed in the lysyl, leucyl, phenylalanyl, and tyrosyl patterns of the dye-treated animals. The comparative patterns of the arginyl-, seryl-, methionyl-, valyl-, histidyl-, and threonyl-tRNA's of normal and precancerous livers were almost identical.

¹ Supported by American Cancer Society Grant P-501D and the Robert A. Welch Foundation Grant G-035.

² American Cancer Society Professor of Biochemistry.

Received 10/ 2/69. Accepted 1/30/70.