This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by DeWys, W. D. Articles by Mantel, N. Search for Related Content PubMed PubMed Citation Articles by DeWys, W. D. Articles by Mantel, N.

Hematopoietic Recovery after Large Doses of Cyclophosphamide: Correlation of Proliferative State with Sensitivity¹

Cancer Chemotherapy National Service Center [W. D. DeW., A. G.], and Biometry Branch, [N. M.], National Cancer Institute, Bethesda, Maryland 20014

Hematological recovery after a large dose of cyclophosphamide was characterized by early rapid recovery of marrow stem cells (colony-forming assay), followed successively by recovery of circulating stem cells (colony-forming assay), total marrow cellularity, and circulating blood cells. This recovery sequence provided a model in which marrow with different proliferative rates could be studied for sensitivity to cyclophosphamide by subjecting animals to a second treatment at various intervals after an initial treatment. The results of this type of study suggest that the proliferative state of a cell population is a determinant of sensitivity to cyclophosphamide.

¹ This study was supported in part by Contract PH 43-64-91 from the Cancer Chemotherapy National Service Center. A preliminary report has been presented (10).

² To whom reprint requests should be sent at the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, N. Y. 14620.

Received 11/10/69. Accepted 2/ 3/70.

This article has been cited by other articles:

				K. Kusano, S. Ebara, K. Tachibana, T. Nishimura, S. Sato, T. Kuwaki, and T. Taniyama A potential therapeutic role for small nonpeptidyl compounds that mimic human granulocyte colony-stimulating factor Blood, February 1, 2004; 103(3): 836 - 842. [Abstract] [Full Text] [PDF]