This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Hewetson, J. F. Articles by Groupé, V. Search for Related Content PubMed PubMed Citation Articles by Hewetson, J. F. Articles by Groupé, V.

Claude's Chicken Tumor Virus-10: Local Variability in Virus Titer and Effect of Amputation¹

Institute of Microbiology, Rutgers University, New Brunswick, New Jersey 08903

Infectivity titrations of halves of individual tumors produced in the wing web of chicks with serial dilutions of chicken tumor virus-10 showed marked variability in titratable virus. No pattern of recoverable virus was apparent and virus-neutralizing antibodies were not detected in sera from the birds. Attempts to prevent the development of chicken tumor virus-10 tumors by amputation immediately after infection failed, and tumors developed at the site of amputation. Chicken tumor virus-10 hyperimmune sera injected i.m. protected against subsequent challenge with homologous virus when administered 1 day before, but not 1 day after, infection.

¹ This work was supported by Grant CA-05175 from the National Cancer Institute.

² Present address: Department of Tumor Biology, Karolinska Institutet, 10401 Stockholm 60, Sweden.

³ Present address: Life Sciences, Inc., 2900 72nd Street North, St. Petersburg, Fla. 33710.

Received 6/30/69. Accepted 2/12/70.