This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Mukerjee, D. Articles by Anderson, D. E. Search for Related Content PubMed PubMed Citation Articles by Mukerjee, D. Articles by Anderson, D. E.

Simian Papovavirus 40 Transformation of Cells from Cancer Patient with XY/XXY Mosaic Klinefelter's Syndrome

The University of Texas M. D. Anderson Hospital and Tumor Institute at Houston, Houston, Texas 77025

Transformation frequency by simian papovavirus 40 of fibroblasts from a lung cancer patient with Klinefelter's syndrome and XY/XXY mosaicism was 3 to 10 times higher than that of fibroblasts from individuals with normal karyotypes and no history of cancer. The patient's XXY cell strain also manifested a 3-fold increase in susceptibility to transformation as compared to his XY cell strain. This observation, coupled with the finding of a high frequency of sex chromatin-positive cells in his tumor, could indicate origin of the tumor from the aneuploid cell population.

¹ Present address: Department of Pathology, The University of Texas Medical Branch, Galveston, Texas 77550.

Received 11/12/69. Accepted 2/12/70.

This article has been cited by other articles:

				A. J. Swerdlow, M. J. Schoemaker, C. D. Higgins, A. F. Wright, P. A. Jacobs, and on behalf of the UK Clinical Cytogenetics Group Cancer Incidence and Mortality in Men with Klinefelter Syndrome: A Cohort Study J Natl Cancer Inst, August 17, 2005; 97(16): 1204 - 1210. [Abstract] [Full Text] [PDF]