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The Effect of Chemotherapy on the Growth Characteristics and Cellular Kinetics of Leukemia L1210¹

Solid Tumor Service, Medicine Branch, National Cancer Institute, NIH, Bethesda, Maryland 20014

The double-labeling technique with thymidine-³H and -¹⁴C was used to study the in vivo effects of chemotherapy on the cell cycle and proliferation characteristics of L1210 leukemia in the ascites form. A divergent effect of 1,3-bis(2-chloroethyl)-1-nitrosourea and cyclophosphamide on the S phase was noted; prolongation of the S phase occurred in cells following lethal injury with 1,3-bis(2-chloroethyl)-1-nitrosourea but not with cyclophosphamide. Studies on the regrowth of the L1210 cells exposed to 1,3-bis(2-chloroethyl)-1-nitrosourea but not sustaining a lethal biochemical lesion demonstrated a normal duration of DNA synthesis and generation time and an alteration of the proliferating pool size.

¹ Presented in part at the 60th Annual Meeting of the American Association for Cancer Research, March 1969, San Francisco, Calif.

Received 6/13/69. Accepted 2/18/70.