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Induction of T Antigen, New Surface Antigen, and Transplantation Immunity by a Nontumorigenic Variant of Type 3 Bovine Adenovirus¹

Institute for Virus Research, Kyoto University, Kyoto, Japan

T antigen and new surface antigen in infected porcine kidney stable cells were induced with a nontumorigenic variant (WB-PS) with an antigenic alteration. WB-PS variant has been isolated from the wild type strain of type 3 bovine adenovirus in procine kidney stable cells. The WB-PS variant multiplied in hamster embryonic cells but a tumorigenic clone BA of type 3 bovine adenovirus did not multiply in the hamster embryonic cells. WB-PS variant also induced transplantation immunity in hamsters against tumor cells transformed by type 3 bovine adenovirus.

¹ This investigation was supported by Grant DRG-890 from the Damon Runyon Memorial Fund for Cancer Research and by the Ministry of Education, Japan.

Received 8/ 4/69. Accepted 2/18/70.