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The Effect of Partial Hepatectomy on the Metabolism of Urethan in Young Adult Mice¹

Departments of Pharmacology [D. E. G., M. L., F. E. S.] and Anatomy [R. A. L.], Baylor College of Medicine, Houston, Texas 77025

The metabolism of carbonyl-¹⁴C urethan was studied in 8- to 10-week-old BALB/c/Ki mice, both intact and after partial hepatectomy. No major differences were noted between intact and operated mice in the urethan concentration in whole blood and liver or in subcellular fractions, DNA, and RNA of liver. Radioactivity was not detected in the blood or liver of intact and operated mice 24 hr after each of 3 injections of radioactive urethan given on alternate days. These observations, taken in conjunction with the results of the preceding paper (13), support the view that the increased rate of cell proliferation after partial hepatectomy enhances the susceptibility of the liver to the carcinogenic effect of urethan.

¹ Supported by USPHS Research Grants CA-06240 and CA-10893 from the National Cancer Institute.

² Present address: Biology Department, University of Missouri-St. Louis, St. Louis, Mo. 63121.

³ To whom requests for reprints should be sent.

Received 7/23/68. Accepted 2/25/70.