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Benzo[]pyrene-metabolizing Enzyme Activity of Livers of Various Strains of Mice

Roswell Park Memorial Institute (New York State Department of Health), Buffalo, New York 14203

Benzo[]pyrene (BP) hydroxylase activity in liver tissue of 6 stocks of mice was assayed. The C57BL/6Ha mice had the highest liver hydroxylase activity, two to three times as high as that in the DBA/2 strain, which had the lowest enzyme activity. The F₁ hybrids of the C57BL/6Ha and C3H/StHa mice had liver hydroxylase levels similar to those of the C3H parent. Conversion of BP into its 1,6-quinone by liver supernatants was highest in the C57BL/6Ha mice, but the differences were not as striking as in the case of hydroxylase activity. After i.p. injection of BP, induction of BP hydroxylase activity was very pronounced in the C57BL/6Ha and C3H/StHa strains and their F₁ hybrid, but no induction was seen in the DBA/2, A/St, and Ha/ICR Swiss mice. Work is in progress to determine whether there is a relationship between enzyme activity and sensitivity to polynuclear aromatic hydrocarbon carcinogens.

¹ Present address: Department of Hygienics, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

Received 9/10/69. Accepted 3/ 3/70.

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